Among sitagliptin users, most (7293; 91%) used sitagliptin as

To identify the dominant factors among interrelated variables, those that were statistically significant in univariate regression were included in a multivariate linear regression model in which observations on the outcome variable (annual rate of change in TB incidence rate) were weighted by 1/variance. Independent variables that had low explanatory power in combination with others were removed one by one the least significant at each step to generate a minimal model containing only variables that were significant at Pt tests. The significance of the multivariate minimal model is given in terms of F statistics.

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pandora bracelets Although statistical differences existed between sitagliptin and non sitagliptin users owing to the large numbers, few clinically important differences existed with the exception that sitagliptin users tended to have higher use of insulin treatment and higher rates of diabetes related complications (table 1). Among sitagliptin users, most (7293; 91%) used sitagliptin as an add on treatment with other oral agents, consistent with current clinical practice guidelines.Table 1 Baseline characteristics according to drug use at any time during follow up. Values are numbers (percentages) unless stated otherwiseView this table:View popupView inlineBy the end of follow up (182409 patient years with a mean duration of 2.5 (SD 1.7) years), our primary composite endpoint had occurred in 14215 (20%) patients: 14121 (19%) patients were admitted to hospital at least once, and 520 (1%) died (table 2). pandora bracelets

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